Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber ER, Chen S, Sigel C, Lowe SW, Jarnagin WR, Thompson CB, Schietinger A, Keshari KR.

Sci Adv. 2022 Apr; 8(14): eabm7985; Published online 2022 Apr 6. doi: 10.1126/sciadv.abm7985

Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. 

Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. 

Cancer Res. 2019 Jan 1;79(1):242-250. doi: 10.1158/0008-5472.CAN-18-2231. Epub 2018 Nov 20. PubMed PMID: 30459151; PubMed Central PMCID: PMC6318024.

Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate. 

Tee SS, Suster I, Truong S, Jeong S, Eskandari R, DiGialleonardo V, Alvarez JA, Aldeborgh HN, Keshari KR.

Mol Cancer Res. 2018 Mar;16(3):453-460. doi: 10.1158/1541-7786.MCR-17-0458. Epub 2018 Jan 12. PubMed PMID: 29330287; PubMed Central PMCID: PMC6662159.

 PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.

Tee SS, Park JM, Hurd RE, Brimacombe KR, Boxer MB, Massoud TF, Rutt BK, Spielman DM.

Oncotarget. 2017 Oct 31;8(53):90959-90968. doi: 10.18632/oncotarget.19630. eCollection 2017 Oct 31. PubMed PMID: 29207616; PubMed Central PMCID: PMC5710897.

Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. 

Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR.

Sci Adv. 2017 Jun;3(6):e1700341. doi: 10.1126/sciadv.1700341. eCollection 2017 Jun. PubMed PMID: 28630930; PubMed Central PMCID: PMC5473678.

Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. 

Tee SS, DiGialleonardo V, Eskandari R, Jeong S, Granlund KL, Miloushev V, Poot AJ, Truong S, Alvarez JA, Aldeborgh HN, Keshari KR.

Sci Rep. 2016 Sep 6;6:32846. doi: 10.1038/srep32846. PubMed PMID: 27597137; PubMed Central PMCID: PMC5011774.