Beyond Fructolysis: Ketohexokinase Orchestrates ER Proteostasis in Nutrient-Stressed Hepatocytes

Elsaid S, Wu X, Hu J, Ambaye N, Tee SS.

Am J Physiol Gastrointest Liver Physiol. 2025 Oct 25. doi: 10.1152/ajpgi.00235.2025. Online ahead of print.

Volumetric brain alterations associated with a high-fat, high-fructose obesogenic diet: Insights from cross-sectional and longitudinal MRI in mice

Jiang L, Zhan C, Elsaid S, Li X, Xu S, Zhuo J, Tee SS.

Biochem Biophys Res Commun. 2025 Nov 1;787:152774. doi: 10.1016/j.bbrc.2025.152774. Epub 2025 Oct 8.

Single-cell Raman imaging reveals fructose impairs brown adipocyte differentiation.

Gupta A, Anantha P, Koresawa H, Xi H, Yang YB, Lee MKH, Fujita K, Tee SS, Barman I.

Biosens Bioelectron. 2025 Dec 15;290:117994. doi: 10.1016/j.bios.2025.117994. Epub 2025 Sep 13.PMID: 40957282

Sweet science: Exploring the impact of fructose and glucose on brown adipocyte differentiation using optical diffraction tomography

Pooja Anantha, Xiangdong Wu, Salaheldeen Elsaid, Piyush Raj, Junkai Hu, Ishan Barman, Sui Seng Tee

J Cell Biochem. 2025 Jun 29;126(6):e70052. doi: 10.1002/jcb.70052

Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing

Anjana Hevaganinge, Eva Lowenstein, Anna Filatova, Mihir Modak, Nandi Thales Mogo, Bryana Rowley, Jenny Yarmowsky, Joshua Ehizibolo, Ravidu Hevaganinge, Amy Musser, Abbey Kim, Anthony Neri, Jessica Conway, Yiding Yuan, Maurizio Cattaneo, Sui Seng Tee, Yang Tao

Scientific Reports volume 15, Article number: 2307 (2025)

Fructose vs. glucose: modulating stem cell growth and function through sugar supplementation

Elsaid S, Wu X, SS Tee

FEBS Open Bio. 2024 Jun 25;. doi: 10.1002/2211-5463.13846. [Epub ahead of print] PubMed PMID: 38923793.

Ketohexokinase-mediated fructose metabolism is lost in hepatocellular carcinoma and can be leveraged for metabolic imaging

Tee SS, Kim N, Cullen Q, Eskandari R, Mamakhanyan A, Srouji RM, Chirayil R, Jeong S, Shakiba M, Kastenhuber ER, Chen S, Sigel C, Lowe SW, Jarnagin WR, Thompson CB, Schietinger A, Keshari KR.

Sci Adv. 2022 Apr; 8(14): eabm7985; Published online 2022 Apr 6. doi: 10.1126/sciadv.abm7985

Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models. 

Dong Y, Eskandari R, Ray C, Granlund KL, Santos-Cunha LD, Miloushev VZ, Tee SS, Jeong S, Aras O, Chen YB, Cheng EH, Hsieh JJ, Keshari KR. 

Cancer Res. 2019 Jan 1;79(1):242-250. doi: 10.1158/0008-5472.CAN-18-2231. Epub 2018 Nov 20. PubMed PMID: 30459151; PubMed Central PMCID: PMC6318024.

Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate. 

Tee SS, Suster I, Truong S, Jeong S, Eskandari R, DiGialleonardo V, Alvarez JA, Aldeborgh HN, Keshari KR.

Mol Cancer Res. 2018 Mar;16(3):453-460. doi: 10.1158/1541-7786.MCR-17-0458. Epub 2018 Jan 12. PubMed PMID: 29330287; PubMed Central PMCID: PMC6662159.

 PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.

Tee SS, Park JM, Hurd RE, Brimacombe KR, Boxer MB, Massoud TF, Rutt BK, Spielman DM.

Oncotarget. 2017 Oct 31;8(53):90959-90968. doi: 10.18632/oncotarget.19630. eCollection 2017 Oct 31. PubMed PMID: 29207616; PubMed Central PMCID: PMC5710897.

Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. 

Jeong S, Eskandari R, Park SM, Alvarez J, Tee SS, Weissleder R, Kharas MG, Lee H, Keshari KR.

Sci Adv. 2017 Jun;3(6):e1700341. doi: 10.1126/sciadv.1700341. eCollection 2017 Jun. PubMed PMID: 28630930; PubMed Central PMCID: PMC5473678.

Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. 

Tee SS, DiGialleonardo V, Eskandari R, Jeong S, Granlund KL, Miloushev V, Poot AJ, Truong S, Alvarez JA, Aldeborgh HN, Keshari KR.

Sci Rep. 2016 Sep 6;6:32846. doi: 10.1038/srep32846. PubMed PMID: 27597137; PubMed Central PMCID: PMC5011774.

Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field. 

Tee SS, DiGialleonardo V, Eskandari R, Jeong S, Granlund KL, Miloushev V, Poot AJ, Truong S, Alvarez JA, Aldeborgh HN, Keshari KR.

Sci Rep. 2016 Sep 6;6:32846. doi: 10.1038/srep32846. PubMed PMID: 27597137; PubMed Central PMCID: PMC5011774.